Visual PROTACPROTAC Examples
Representative PROTACs illustrate the warhead–linker–E3 ligand architecture. Use Visual PROTAC to compute molecular weight and linker length for your own designs.
Example molecules
Reference only; structures and targets are simplified.
| Name | Target | E3 | Linker type | Notes |
|---|---|---|---|---|
| ARV-771 (BET) | BET bromodomain | VHL | PEG-based | Early BET degrader |
| ARV-110 | Androgen receptor | CRBN | Flexible | Clinical |
| dBET1 | BET | CRBN | Short alkyl/PEG | Proof-of-concept |
| MZ1 | BRD4 | VHL | PEG | Structural studies |
Design your own
Use the PROTAC Molecular Weight tool to enter warhead, linker, and E3 ligand (SMILES or built-in options) and get combined MW and physicochemical properties. See the Linker Library for common linkers.